Amino acid acylation: a mechanism of nitrogen excretion in inborn errors of urea synthesis

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Science  08 Feb 1980:
Vol. 207, Issue 4431, pp. 659-661
DOI: 10.1126/science.6243418


Treatment of a patient deficient in carbamyl phosphate synthetase with benzoate or phenylacetic acid resulted in an increase in urinary nitrogen, which could be accounted for by the respective amino acid acylation product, hippurate or phenylacetylgultamine. Benzoate treatment of four hyperammonemic comatose patients led to clinical improvement and a return of plasma ammonium levels toward normal.