Distribution of active gene sequences: a subset associated with tightly bound chromosomal proteins

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Science  08 Feb 1980:
Vol. 207, Issue 4431, pp. 661-662
DOI: 10.1126/science.7352280


The distribution of active polyadenylate-messenger RNA sequences in fractionated chicken liver chromatin was examined. A portion of these active gene sequences is concentrated in a DNA fraction retained by tightly bound nonhistone chromosomal proteins, while the nonretained DNA fraction is substantially depleted of a portion of these sequences. These findings suggest that the tightly bound nonhistones are physically associated with a subset of active gene sequences.