Reports

Localization of lysyl oxidase in hen oviduct: implications in egg shell membrane formation and composition

Science  04 Apr 1980:
Vol. 208, Issue 4439, pp. 55-56
DOI: 10.1126/science.6102412

Abstract

Lysyl oxidase activity was found in the isthmus (the membrane-forming region) of the hen's oviduct in a copper-rich region proximal to the shell gland. Desmosine and isodesmosine, cross-linking compounds associated with mature elastin, were found in hydrolysates of the shell membrane, confirming the necessity for lysyl oxidase in its biosynthesis. Shell membranes from hens fed a copper-deficient diet or a diet supplemented with beta-aminopropionitrile had a reduced content of desmosine and isodesmosine.

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