Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro

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Science  25 Apr 1980:
Vol. 208, Issue 4442, pp. 402-404
DOI: 10.1126/science.6245446


Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.