Calcification inside artificial hearts: inhibition by warfarin-sodium

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Science  09 May 1980:
Vol. 208, Issue 4444, pp. 601-603
DOI: 10.1126/science.7367883


Intracavitary calcium phosphate deposits were observed in smooth, elastomeric blood pump sacs implanted in male calves for periods of 115 to 166 days. These deposits occurred predominantly on the flexing surface of the sacs. In contrast, similar pump sacs remained generally free of mineral deposits for up to 150 days in calves treated with the anticoagulant warfarin-sodium. These results implicate a vitamin K-dependent process in calcium phosphate deposition on elastomeric sacs.