Neurotransmitter receptor binding in bovine cerebral microvessels

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Science  09 May 1980:
Vol. 208, Issue 4444, pp. 610-612
DOI: 10.1126/science.6102801


Purified preparations of microvessels from bovine cerebral cortex contain substantial levels of alpha-adrenergic, beta-adrenergic, and histamine 1 receptor binding sites but only negligible serotonin, muscarinic cholinergic, opiate, and benzodiazepine receptor binding. Norepinephrine and histamine may be endogenous regulators of the cerebral microcirculation at the observed receptors.