Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450

Science  30 May 1980:
Vol. 208, Issue 4447, pp. 1031-1033
DOI: 10.1126/science.7375915

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Antibody to the major purified cytochrome P-450 induced by 3-methylcholanthrene in rat liver strongly inhibits aryl hydrocarbon hydroxylase activity of uninduced and benz[a]anthracene-induced human monocytes and lymphocytes. Antibody to the cytochrome P-450 induced by phenobarbital has relatively little or no effect on the aryl hydrocarbon hydroxylase activity of the same human cells.