Reports

Cholecystokinin receptors in the brain: characterization and distribution

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Science  06 Jun 1980:
Vol. 208, Issue 4448, pp. 1155-1156
DOI: 10.1126/science.6246582

Abstract

Specific cholecystokinin binding sites in particulate fractions of rat brain were measured with iodine 125-labeled Bolton-Hunter cholecystokinin, a cholecystokinin analog that has full biological activity. Binding was detected in brain regions known to contain immunoreactive cholecystokinin. Binding was saturable, reversible, of high affinity (dissociation constant, 1.7 x 10(-9) M), and was inhibited by cholecystokinin analogs but not by unrelated hormones.

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