Clinical radioimmunodetection of cancer with radioactive antibodies to human chorionic gonadotropin

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Science  13 Jun 1980:
Vol. 208, Issue 4449, pp. 1284-1286
DOI: 10.1126/science.7375942


Injection of iodine-131-labeled goat immunoglobulin G antibody to human chorionic gonadotropin (hCG) into patients with hCG-secreting trophoblastic and germinal tumors permitted tumor detection and location by external gamma-ray scintigraphy. Excision of one of the metastatic tumors located by this method indicated a tumor/nontumor ration of 39.29. The method appears to offer a new clinical tool for precisely locating hCG-producing tumors in the body, even when tumor identification by other clinical methods has failed.