Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats

See allHide authors and affiliations

Science  11 Jul 1980:
Vol. 209, Issue 4453, pp. 305-307
DOI: 10.1126/science.7384808


A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.