Plaminogen is synthesized by primary cultures of rat hepatocytes

Science  18 Jul 1980:
Vol. 209, Issue 4454, pp. 408-410
DOI: 10.1126/science.7384814


The accumulation of rat plasminogen in the medium of primary monolayer cultures of adult parenchymal hepatocytes was detected with a quantitative immunological assay. These primary cultures synthetisized and secreted both circulating isozymic forms of plasminogen at rates sufficient to account for the majority of the in vivo plasminogen turnover.