Reports

Limitations of metabolic activation systems used with in vitro tests for carcinogens

+ See all authors and affiliations

Science  25 Jul 1980:
Vol. 209, Issue 4455, pp. 503-505
DOI: 10.1126/science.6771871

Abstract

Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results.

Related Content