Environmental influences on body weight and behavior in developing rats after neonatal 6-hydroxydopamine

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Science  08 Aug 1980:
Vol. 209, Issue 4457, pp. 715-717
DOI: 10.1126/science.7394533


There is less hyperactive motor activity and better avoidance performance in rat pups treated with 6-hydroxydopamine as neonates and reared with vehicle-treated littermates than in pups reared in litters composed solely of other 6-hydroxydopamine-treated animals. Thus, in this experimental model of hyperactivity, an environmental manipulation provides an alternative to pharmacologic agents in reducing activity and improving learning performance.