Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers

See allHide authors and affiliations

Science  15 Aug 1980:
Vol. 209, Issue 4458, pp. 813-815
DOI: 10.1126/science.6105709


Microinjection of L-glutamate into the intermediate nucleus tractus solitarii in anesthetized rats elicits hypotension, bradycardia, and apnea, simulating baroreceptor reflexes. Ablation of the nodose ganglion results in selective reduction of high-affinity uptake of L-glutanate in the nucleus tractus solitarii. L-Glutamate may be the neurotransmitter of afferent nerve fibers from arterial baroreceptors.