Dexamethasone fails to suppress beta-endorphin plasma concentrations in humans and rhesus monkeys

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Science  15 Aug 1980:
Vol. 209, Issue 4458, pp. 827-828
DOI: 10.1126/science.6250217


In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating beta-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary beta-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate beta-endorphin secretion in the same way.