Male contraception; synergism of gonadotropin-releasing hormone analog and testosterone in suppressing gonadotropin

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Science  22 Aug 1980:
Vol. 209, Issue 4459, pp. 936-938
DOI: 10.1126/science.6773142


Long-term administration of either superactive analog's of gonadotropin-releasing hormone or of testosterone suppresses gonadotropin secretion in male animals and humans. Testosterone administered in combination with gonadotropin-releasing hormone analog further suppresses serum gonadotropin levels in male rats. This observation indicates synergistic activity and suggests that the gonadotropin-releasing hormone analog and testosterone act at independent sites within the hypothalamic-pituitary axis. The primary actions of superactive analog are probably mediated by changes at a postreceptor site in the pituitary gonadotropin-secreting cells.