Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats

Science  05 Sep 1980:
Vol. 209, Issue 4461, pp. 1142-1143
DOI: 10.1126/science.7403876


Intrahypothalamic injections of 100 picomoles of pentagastrin or natural gastrin promptly increased secretion of gastric acid in conscious rats. The response was blocked by atropine and by vagotomy. The same doses, injected intravenously or into other forebrain sites, did not increase secretion, nor did intrahypothalamic injections of other peptides common to the gut and brain.