Stress-induced eating is mediated through endogenous opiates

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Science  12 Sep 1980:
Vol. 209, Issue 4462, pp. 1259-1261
DOI: 10.1126/science.6250222


The interaction of endogenous opiates and stress-induced eating in rats was evaluated by pharmacological manipulation. Eating induced by the tail-pinch method was inhibited by the opitate antagonist naloxone; after being repeatedly stressed over a 10-day period and then given nalozone, the rats behaved in a manner indistinguishable from the "wet-dog" shakes of opiate withdrawal. Thus endogenous opiates may have a role in the control of stress-related eating, a finding that may have therapeutic implications for humans.