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Recombination of dispersed repeated DNA sequences in yeast

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Science  19 Sep 1980:
Vol. 209, Issue 4463, pp. 1380-1384
DOI: 10.1126/science.6251545


Yeast transformation can be used to insert new sequence arrangements into a variety of chromosomal locations by homologous recombination. These newly inserted sequences can recombine with similar sequences located on other chromosomes. In these events, information is duplicated without being lost at the site from which it is derived. Similar mechanisms might be utilized by cells to provide new functions during development or differentiation.