Antireproductive effects of a potent gonadotropin-releasing hormone antagonist in the male rat

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Science  03 Oct 1980:
Vol. 210, Issue 4465, pp. 93-95
DOI: 10.1126/science.6774418


Administration of a potent antagonist of gondadotropin-releasing hormone (GnRH) antagonist [Ac-dehydro-Pro1, pCl-D-Phe2, D-Trp3,6]-N alpha-MeLeu7-GnRH to adult male rats for 2 weeks resulted in decreased testosterone production and sexual organ weights and in disrupted spermatogenesis. The results demonstrate the essential role of gonadotropin-releasing hormone in the maintenance of reproductive functions and have implications for the regulation of male fertility.