Direct measurement of microvascular pressures in the isolated perfused dog lung

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Science  17 Oct 1980:
Vol. 210, Issue 4467, pp. 327-328
DOI: 10.1126/science.7423192


Microvascular pressures in the pulmonary circulation were measured under the pleural surface of the isolated perfused dog lung by the servo-null technique. Strong glass micropipettes with short beveled tips were used, with a suction ring to stabilize the lung's surface. Of the total vascular resistance, 45 percent was in the alveolar wall capillaries themselves. Most of the remaining resistance was in the arterioles. There was negligible pressure drop in venules with diameters larger than 20 micrometers.