Neuronal control of acetylcholine receptor turnover rate at a vertebrate neuromuscular junction

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Science  31 Oct 1980:
Vol. 210, Issue 4469, pp. 550-551
DOI: 10.1126/science.7423205


The turnover rate of acetylcholine receptors at neuromuscular junctions in mice increases progressively after denervation and, after 15 days, reaches a half-time of 30 z 5 hours. Denervation thus causes the clustered junctional acetylcholine receptors to assume the rapid turnover characteristic of extrajunctional receptors before innervation.