Articles

DNA methylation and gene function

Science  07 Nov 1980:
Vol. 210, Issue 4470, pp. 604-610
DOI: 10.1126/science.6254144

Abstract

In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive. However, there is now reason to believe, from recent studies, that DNA methylation is a key element in the hierarchy of control mechanisms that govern vertebrate gene function and differentiation.

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