Reports

Subcellular origin of cholinergic transmitter release from mouse brain

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Science  07 Nov 1980:
Vol. 210, Issue 4470, pp. 641-642
DOI: 10.1126/science.7433989

Abstract

Samples of minced mouse forebrain were treated in a way that resulted in a high ratio of false cholinergic transmitter (acetylhomocholine) to true transmitter (acetylcholine) in a synaptic vesicle fraction, and a low ratio of false to true transmitter in the nerve terminal cytoplasm. The spontaneous release of cholinergic transmitters from this minced tissue occurred independently of calcium and had a ratio of false to true transmitter similar to that of the cytoplasm, whereas the evoked transmitter release required calcium and had a ratio of false to true transmitter similar to that of the vesicular fraction.