Oral contraceptives, lanosterol, and platelet hyperactivity in rat

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Science  07 Nov 1980:
Vol. 210, Issue 4470, pp. 642-644
DOI: 10.1126/science.7433990


Lanosterol, a cholesterol precursor that increases considerably in the platelets of rats treated with oral contraceptives, was incubated with either platelet-rich plasma or washed platelet suspension. After 2 minutes there was a remarkable dose-related increase in platelet activity. This platelet hyperactivity was measured by clotting time and platelet aggregation could not be reproduced by cholesterol or ethinylestradiol.