Reorganization of the axon membrane in demyelinated peripheral nerve fibers: morphological evidence

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Science  07 Nov 1980:
Vol. 210, Issue 4470, pp. 661-663
DOI: 10.1126/science.6159685


Cytochemical staining of demyelinated peripheral axons revealed two types of axon membrane organization, one of which suggests that the demyelinated axolemma acquires a high density of sodium channels. Ferric ion-ferrocyanide stain was confined to a restricted region of axon membrane at the beginning of a demyelinated segment or was distributed throughout the demyelinated segment of axon. The latter pattern represents one possible morphological correlate of continuous conduction through a demyelinated segment and suggests a reorganization of the axolemma after demyelination.

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