Role of ornithine decarboxylase in cardiac growth and hypertrophy

Science  14 Nov 1980:
Vol. 210, Issue 4471, pp. 793-794
DOI: 10.1126/science.6449079


Inhibition of cardiac ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced hypertrophy. Hypertrophy caused by triiodothyronine was not prevented by DFMO. There appear to be both ODC-dependent and ODC-independent processes contributing to the subcellular mechanisms associated with growth, which must be considered in the potential laboratory and clinical use of DFMO.