Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria

See allHide authors and affiliations

Science  28 Nov 1980:
Vol. 210, Issue 4473, pp. 1021-1023
DOI: 10.1126/science.7434011


Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H]proline collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.