Reports

Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria

Science  28 Nov 1980:
Vol. 210, Issue 4473, pp. 1021-1023
DOI: 10.1126/science.7434011

Abstract

Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H]proline collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.

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