Insulin receptors: differences in structural organization on adipocyte and liver plasma membranes

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Science  05 Dec 1980:
Vol. 210, Issue 4474, pp. 1127-1128
DOI: 10.1126/science.7003710


Comparison was made of the distribution of the insulin receptor sites on adipocyte and liver plasma membranes by using ferritin-insulin. Two-thirds of the occupied insulin receptors on adipocytes occurred in groups of two or more whereas up to two-thirds of the receptors on liver occurred as single receptors. Ferritin-insulin did not cause aggregation of the receptor sites in either tissue. The naturally occurring groups of receptors on adipocyte membranes may play a role in the greater sensitivity of adipocytes to insulin.