Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation

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Science  05 Dec 1980:
Vol. 210, Issue 4474, pp. 1150-1152
DOI: 10.1126/science.7003711


Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 X 10(6)) from BALB/c to C3H/HeJ chimeras (>90 percent circulating donor-type cells) without graft versus host disease. beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.