Evidence for homologous actions of pro-opiocortin products

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Science  12 Dec 1980:
Vol. 210, Issue 4475, pp. 1247-1249
DOI: 10.1126/science.6254152


alpha-Melanocyte-stimulating hormone (alpha-MSH), a modified fragment of adrenocorticotropic hormone, derives from the same biosynthetic route as beta-endorphin and is stored by the same arcuate neurons. Microinjection of alpha-melanocyte-stimulating hormone and several related peptides into the periaqueductal gray matter significantly reduced responsiveness to pain and had a behavioral profile similar to that produced by beta-endorphin.