Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways

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Science  12 Dec 1980:
Vol. 210, Issue 4475, pp. 1252-1253
DOI: 10.1126/science.6254154


Vasoactive intestinal peptide, a smooth-muscle relaxant neuropeptide with neurotransmitter properties, was relaxed during electrical field stimulation of guinea pig trachea. The amount released correlated with the degree of relaxation, and the release was blocked by tetrodotoxin. Prior incubation of the trachea with antiserum to vasoactive intestinal peptide reduced the relaxation. Thus vasoactive intestinal peptide may mediate the nonadrenergic relaxation of tracheal smooth muscle.