Glucose suppresses basal firing and haloperidol-induced increases in the firing rate of central dopaminergic neurons

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Science  12 Dec 1980:
Vol. 210, Issue 4475, pp. 1269-1271
DOI: 10.1126/science.6254155


In the rat, doses of glucose sufficient to raise glucose concentrations in the blood to levels equivalent to those produced by a meal or stress suppress the firing of dopamine-containing neurons located within the substantia nigra. Glucose also prevents or reverses the increase in discharge rates of dopaminergic cells normally elicited by the antipsychotic agent haloperidol.