Fasting associated with decrease in hypothalamic beta-endorphin

Science  12 Dec 1980:
Vol. 210, Issue 4475, pp. 1271-1272
DOI: 10.1126/science.6254156


In rats that were fasted for 2 to 3 days there was a decline in hypothalamic, but not pituitary, beta-endorphin. There was no change in pituitary or hypothalamic adrenocorticotropin content as a result of fasting. Endogenous opiates may be involved in physiological adaptation to fasting.