"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide

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Science  19 Dec 1980:
Vol. 210, Issue 4476, pp. 1347-1349
DOI: 10.1126/science.210.4476.1347


Benzo[a]pyrene deposited on a glass fiber filter reacts rapidly in the dark or light with ambient levels of ozone to yield a mixture of products that display strong direct mutagenicity in the Ames assay. The major stable contributor to this activity has been identified as benzo[a]pyrene-4,5-oxide, a DNA-binding metabolite in biological systems, known to be a strong direct mutagen with Salmonella typhimurium strain TA98.