Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor

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Science  19 Dec 1980:
Vol. 210, Issue 4476, pp. 1363-1365
DOI: 10.1126/science.6254158


Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.