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Mental symptoms in Huntington's disease and a possible primary aminergic neuron lesion

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Science  19 Dec 1980:
Vol. 210, Issue 4476, pp. 1369-1371
DOI: 10.1126/science.6449080

Abstract

Monoamine oxidase activity was higher in the cerebral cortex and basal ganglia of patients dying from Huntington's disease than in controls. Enzyme kinetics and multiple substrate studies indicated that the increased activity was due to elevated concentrations of monoamine oxidase type B. Concentrations of homovanillic acid were increased in the cerebral cortex but not in the basal ganglia of brains of patients with Huntington's disease. These changes may represent a primary aminergic lesion that could underlie some of the mental symptoms of this disease.

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