Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine

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Science  02 Jan 1981:
Vol. 211, Issue 4477, pp. 63-65
DOI: 10.1126/science.6255563


A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. Video intensification fluorescence microscopy indicates that binding occurs at the plasma membrane. Diffusion coefficients, obtained by fluorescence photobleaching recovery, are consistent with binding to a protein receptor on the cell surface.