Cyclophosphamide-induced spermatogenic effects detected in the F1 generation by behavioral testing

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Science  02 Jan 1981:
Vol. 211, Issue 4477, pp. 80-82
DOI: 10.1126/science.7444453


Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.