Phenytoin-induced teratogenesis: a mouse model

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Science  30 Jan 1981:
Vol. 211, Issue 4481, pp. 483-484
DOI: 10.1126/science.7455686


Malformations associated with the fetal hydantoin syndrome have been reproduced in a mouse model. The occurrence of these defects was correlated with maternal serum concentrations, but not with maternal or fetal genotype or the presence of a seizure disorder.