Myosin phosphorylation and the cross-bridge cycle in arterial smooth muscle

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Science  30 Jan 1981:
Vol. 211, Issue 4481, pp. 495-497
DOI: 10.1126/science.6893872


Phosphorylation of the 20,000-dalton light chain of myosin is closely correlated with cross-bridge cycling in arterial smooth muscle. Evidence is presented that dephosphorylation can produce an attached, noncycling cross-bridge (latch-bridge) which is responsible for the high economy of force maintenance in this tissue.