Membrane conductance and action potential of a regenerating axonal tip

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Science  13 Feb 1981:
Vol. 211, Issue 4483, pp. 709-712
DOI: 10.1126/science.7455707


The electrical membrane properties of axotomized and regenerating giant axons from the nerve cord of the cockroach Periplaneta americana were studied. Immediately after axotomy there was a decrease in resting potential, input resistance, and action potential amplitude near the cut end. This decrease was followed by the disappearance of the sodium-dependent action potential; an increase in the resting membrane conductance to K+, Na+, and Ca2+; and the appearance of a calcium-dependent action potential.