Exposure of newborn rats to pharmacologically active compounds may permanently alter carcinogen metabolism

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Science  13 Feb 1981:
Vol. 211, Issue 4483, pp. 719-721
DOI: 10.1126/science.7455708


Administration of phenobarbital to mother rats during early lactation causes long-term, perhaps permanent, alteration of hepatic microsomal mixed-function oxidase activity and aflatoxin B1 adduct formation in the adult male offspring. These findings suggest that perinatal exposure to pharmacologically active compounds may be a determinant of cancer risk.