Clocked cell cycle clocks

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Science  06 Mar 1981:
Vol. 211, Issue 4486, pp. 1002-1013
DOI: 10.1126/science.7008196


The cell division cycle of both mammalian cells and microorganisms, which apparently has both deterministic and probabilistic features, is a clock of sorts in that the sequence of events that comprise it measures time under a given set of environmental conditions. The cell division cycle may itself be regulated by a programmable clock that, under certain conditions, can generate circadian periodicities by interaction with a circadian pacemaker. These clocks must insert time segments into the cell division cycle in order to generate the observed variability in cellular generation times.