Trisomic hemopoietic stem cells of fetal origin restore hemopoiesis in lethally irradiated mice

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Science  13 Mar 1981:
Vol. 211, Issue 4487, pp. 1175-1177
DOI: 10.1126/science.7466390


Autosomal trisomy in the mouse is invariably associated with fetal or early postnatal death. Hemopoietic stem cells from fetuses trisomic for chromosome 12 or 19 can be rescued by transplantation into lethally irradiated mice. These trisomic cells restore hemopoiesis, including lymphopoiesis, in the irradiated mice and establish a permanent and almost complete engraftment. There is no evidence that hemopoietic cells with trisomy 12 or 19 are cytogenetically unstable.