Reports

Aspirin prevention of cholesterol gallstone formation in prairie dogs

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Science  27 Mar 1981:
Vol. 211, Issue 4489, pp. 1429-1431
DOI: 10.1126/science.7466399

Abstract

When prairie dogs (Cynomys ludovicianus) are fed a diet containing cholesterol, a marked increase in gallbladder mucin secretion parallels the evolution of cholesterol supersaturated bile. Gelation of mucin precedes the precipitation of cholesterol liquid and solid crystals and the development of gallstones. Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile. This suggests that gallbladder mucin is a nucleation matrix for cholesterol gallstones.

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