Repair of the ultraviolet-irradiated male genome in fertilized mouse eggs

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Science  27 Mar 1981:
Vol. 211, Issue 4489, pp. 1431-1433
DOI: 10.1126/science.7466400


Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with ultraviolet light, indicating a capacity for excision repair. Furthermore, damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.