F-cell production in sickle cell anemia: regulation by genes linked to beta-hemoglobin locus

Science  27 Mar 1981:
Vol. 211, Issue 4489, pp. 1441-1444
DOI: 10.1126/science.6162200


Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the beta S-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.