Potent contact allergen in the rubber plant guayule (Parthenium argentatum)

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Science  27 Mar 1981:
Vol. 211, Issue 4489, pp. 1444-1445
DOI: 10.1126/science.7466403


Chemical and dermatotoxicological investigations of the natural and processed resin of the Mexican rubber plant, guayule (Parthenium argentatum), has established the presence of a sesquiterpene cinnamic acid ester (guayulin A) that is a potent elicitor of allergic contact dermatitis in experimental animals. The guayule contact allergen is comparable to the poison ivy skin allergens as an elicitor of dermatitis in sensitized guinea pigs.