Chemical impurity produces extra compound eyes and heads in crickets

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Science  03 Apr 1981:
Vol. 212, Issue 4490, pp. 51-53
DOI: 10.1126/science.6782672


A chemical impurity isolated from commercially purchased acridine causes cricket embryos to develop extra compound eyes, branched antennae, extra antennae, and extra heads. Purified acridine does not produce similar duplications of cricket heads or head structures nor do the substituted acridines proflavine, acriflavine, or acridine orange. A dose-response relation exists such that the number and severity of abnormalities increase with increasing concentration of the teratogen.